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Naphazoline hydrochloride



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Product Code : LC4191

Product Specification
LC4191 Naphazoline hydrochloride
suitable for use as an active pharmaceutical ingredient api Ph Eur,BP,USP

 

Order number Packaging Quantity Price €
AC31191
 Plastic bottle 1 kg Inquire

 

Product information
Grade Ph Eur,BP,USP
Synonyms 2-(1-Naphthylmethyl)imidazolinium chloride
Hill Formula C14H15ClN2
HS Code 2933 29 10
EC number 208-989-2
Molar mass 246.74 g/mol
CAS number 550-99-2

 

Chemical and physical data
Solubility 170 g/l (20 Â°C)
Melting point 255 - 260 Â°C decomposes
Molar mass 246.74 g/mol
Bulk density 450 kg/m3
pH value 5.0 - 6.6 (10 g/l, H2O, 20 Â°C)

 

Safety information
Storage class 10 - 13 Other liquids and solids
WGK WGK 3 highly water endangering
Disposal 3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

 

Transport information
Declaration (transport by sea) IMDG-Code UN 2811 TOXIC SOLID, ORGANIC, N.O.S.(NAPHAZOLINE HYDROCHLORIDE), 6.1, II
Declaration (transport by air) IATA-DGR UN 2811 TOXIC SOLID, ORGANIC, N.O.S.(NAPHAZOLINE HYDROCHLORIDE), 6.1, II

 

Specifications
Assay
- alkalimetric, calculated on dried substance		 99.0 - 101.0 %
- HPLC, calc. on dried substance 98.0 - 102.0 %
Identity
- IR-spectrum		 conforms
- UV-spectrum conforms
- Chloride conforms
Appearance white or almost white, crystalline powder
Appearance of solution (10 g/l, water) clear and colourless
pH (10 g/l, water) 5.0 - 6.6
Acidity or alkalinity conforms
Residual solvents (Ph.Eur./USP/ICH) class 2 (Toluene) ≤ 80 ppm
Residual solvents (Ph.Eur./USP/ICH) class 3 (Acetone) ≤ 1000 ppm
Residual solvents (Ph. Eur./USP/ICH) of class 3 (Propan-2-ol) ≤ 5000 ppm
Diisopropylether ≤ 500 ppm
Other residual solvents (Ph. Eur./USP/ICH) excluded by the manufacturing process
Related substances (HPLC)
- Naphthylacetylethylenediamine
 ≤ 0.1 %
- Largest unspecified impurity ≤ 0.10 %
- Sum of all impurities ≤ 0.5 %
Ordinary impurities (TLC) ≤ 2.0 %
Sulfated ash (600 Â°C) ≤ 0.1 %
Loss on drying (105 Â°C, 2 h) ≤ 0.5 %
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